Sebastian Schmidl

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Sebastian Schmidl

Sebastian Schmidl

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Biography

Texas A&M International University - Science

Assistant Professor & RELLIS Coordinator of the TAMUT Biology Program
Higher Education
Sebastian
Schmidl
Bryan/College Station, Texas Area
Expertise in microbiology, molecular and cellular biology, bioengineering, synthetic biology, metabolic and gene regulatory networks, infectious diseases, and cell signaling.

Experience

  • Georg-August-Universität Göttingen

    Doctoral Fellow

    Dissertation Title: “Pathogenicity of a minimal organism: Role of protein phosphorylation in Mycoplasma pneumoniae”
    Advisor: Dr. Jörg Stülke

    • Analyzed the Ser/Thr/Tyr phosphoproteome of M. pneumoniae regarding evolutionary constraints underlying the conservation of phosphorylation sites.
    • Isolated kinase and phosphatase mutants to study phosphorylation events that are crucial for cell adhesion to human host cells using (phospho)proteomic profiling.

    Side project: “Impact of glycerol and phospholipid metabolism on virulence in Mycoplasma pneumoniae”

    • Characterized the influence of the glycerophosphodiesterase GlpQ on phospholipid metabolism and bacterial pathogenicity using biochemical, genetic, and physiological studies.
    • Combined large-scale proteome and transcriptome analyses to examine regulatory effects caused by GlpQ activity.

    • Mentored and trained several undergraduate students.
    • Assisted in lab management by purchasing lab supplies and equipment.

  • Georg-August-Universität Göttingen

    Postdoctoral Research Associate

    Project: "Investigation of transporters affecting pathogenicity of Mycoplasma pneumoniae”
    PI: Dr. Jörg Stülke

    • Performed a genome-wide screen to identify transport protein and lipoprotein mutants involved in host-pathogen interactions.
    • Examined these mutants for altered physiology under specific growth conditions and impaired cytotoxicity toward human host cells.

    • Mentored and trained undergraduate and graduate students as well as technicians.

  • Texas A&M International University

    Assistant Professor

    Exploring the microbial world with special focus on host-pathogen interactions.

  • Rice University

    Postdoctoral Research Fellow

    Project: "Studying cell signaling in Escherichia coli by engineering artificial sensory systems"
    PI: Jeffrey J. Tabor, Ph.D.

    • Optimized light-switchable two-component signal transduction systems for the spatiotemporal control of gene expression using genetic refactoring and protein engineering.
    • Engineered a novel cell communication module based on nitric oxide as the signaling molecule.
    • Designed and constructed synthetic signaling proteins with modified input-output properties based on rational protein fusion and domain shuffling strategies.
    • Developed a framework for the modular reconstruction of signaling pathways that can be used to engineer high-performance sensors for scientific, medical, and industrial applications.

    • Mentored and trained several undergraduate and graduate students.
    • Managed laboratory functions including ordering lab supplies and equipment as well as ensuring safety standards as the lab safety officer.

  • Texas A&M University-Texarkana

    Assistant Professor & RELLIS Coordinator of the TAMUT Biology Program

    Building a successful STEM program.

  • University of California San Diego

    Research Intern

    Project: “Phylogenetic analysis of the prpC operon in bacteria”
    Advisor: Milton H. Saier, Jr., Ph.D.

    • Analyzed with bioinformatics tools the conservation of kinase/phosphatase gene clusters in the context of genome reduction in bacterial pathogens.

Education

  • Georg-August-Universität Göttingen

    Diploma Degree

    Biology, General
    Diploma Thesis Title: “Control of the HPr kinase activity of Mycoplasma pneumoniae” Advisor: Dr. Jörg Stülke

  • Georg-August-Universität Göttingen

    Doctor of Science (Dr. rer. nat.)

    Biology, General
    Dissertation Title: “Pathogenicity of a minimal organism: Role of protein phosphorylation in Mycoplasma pneumoniae” Advisor: Dr. Jörg Stülke

  • Thesis Award of the Faculty of Biology



  • Georg-August-Universität Göttingen

    Doctoral Fellow


    Dissertation Title: “Pathogenicity of a minimal organism: Role of protein phosphorylation in Mycoplasma pneumoniae” Advisor: Dr. Jörg Stülke • Analyzed the Ser/Thr/Tyr phosphoproteome of M. pneumoniae regarding evolutionary constraints underlying the conservation of phosphorylation sites. • Isolated kinase and phosphatase mutants to study phosphorylation events that are crucial for cell adhesion to human host cells using (phospho)proteomic profiling. Side project: “Impact of glycerol and phospholipid metabolism on virulence in Mycoplasma pneumoniae” • Characterized the influence of the glycerophosphodiesterase GlpQ on phospholipid metabolism and bacterial pathogenicity using biochemical, genetic, and physiological studies. • Combined large-scale proteome and transcriptome analyses to examine regulatory effects caused by GlpQ activity. • Mentored and trained several undergraduate students. • Assisted in lab management by purchasing lab supplies and equipment.

  • Georg-August-Universität Göttingen

    Postdoctoral Research Associate


    Project: "Investigation of transporters affecting pathogenicity of Mycoplasma pneumoniae” PI: Dr. Jörg Stülke • Performed a genome-wide screen to identify transport protein and lipoprotein mutants involved in host-pathogen interactions. • Examined these mutants for altered physiology under specific growth conditions and impaired cytotoxicity toward human host cells. • Mentored and trained undergraduate and graduate students as well as technicians.

Publications

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • A trigger enzyme in Mycoplasma pneumoniae: Impact of the glycerophosphodiesterase GlpQ on virulence and gene expression

    PLoS Pathog 7: e1002263

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • A trigger enzyme in Mycoplasma pneumoniae: Impact of the glycerophosphodiesterase GlpQ on virulence and gene expression

    PLoS Pathog 7: e1002263

  • Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence

    Infect Immun 81: 896-904

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • A trigger enzyme in Mycoplasma pneumoniae: Impact of the glycerophosphodiesterase GlpQ on virulence and gene expression

    PLoS Pathog 7: e1002263

  • Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence

    Infect Immun 81: 896-904

  • In vitro phosphorylation of key metabolic enzyme from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism

    J Mol Microbiol Biotechnol 18: 129-140

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • A trigger enzyme in Mycoplasma pneumoniae: Impact of the glycerophosphodiesterase GlpQ on virulence and gene expression

    PLoS Pathog 7: e1002263

  • Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence

    Infect Immun 81: 896-904

  • In vitro phosphorylation of key metabolic enzyme from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism

    J Mol Microbiol Biotechnol 18: 129-140

  • Mycoplasma pneumoniae thymidine phosphorylase

    Nucleosides Nucleotides Nucleic Acids 33: 296-304

  • "Mycoplasma and Spiroplasma" in Encyclopedia of Microbiology (M. Schaechter, ed.)

    Elsevier, Oxford. p. 208-219

  • Interactions between glycolytic enzymes of Mycoplasma pneumoniae

    J Mol Microbiol Biotechnol 19: 134-139

  • Refactoring and optimization of light-switchable Escherichia coli two-component systems

    ACS Synth Biol 3: 820-831.

  • The phosphoproteome of the minimal bacterium Mycoplasma pneumoniae: Analysis of the complete known Ser/Thr kinome suggests the existence of novel kinases

    Mol Cell Proteomics 9: 1228-1242

  • Upregulation of thymidine kinase activity compensates for loss of thymidylate synthase activity in Mycoplasma pneumoniae

    Mol Microbiol 77: 1502-1511

  • A trigger enzyme in Mycoplasma pneumoniae: Impact of the glycerophosphodiesterase GlpQ on virulence and gene expression

    PLoS Pathog 7: e1002263

  • Implication of glycerol and phospholipid transporters in Mycoplasma pneumoniae growth and virulence

    Infect Immun 81: 896-904

  • In vitro phosphorylation of key metabolic enzyme from Bacillus subtilis: PrkC phosphorylates enzymes from different branches of basic metabolism

    J Mol Microbiol Biotechnol 18: 129-140

  • Mycoplasma pneumoniae thymidine phosphorylase

    Nucleosides Nucleotides Nucleic Acids 33: 296-304

  • The stability of cytadherence proteins in Mycoplasma pneumoniae requires activity of the protein kinase PrkC

    Infect Immun 78: 184-192

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  • Sebastian Schmidl (80% Match)
    Assistant Professor
    Texas A&M International University - Texas A&m International University

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