University of Hawaii - Psychology
Sam
O'Hanlon
University of Hawaii at Manoa
Oregon State University
Dakota State University
Honolulu
HI
Honolulu
HI
University of Hawaii at Manoa
Dakota State University
Oregon State University
Corvallis
Oregon
Adjunct Instructor
Honolulu
HI
Graduate Assistant
University of Hawaii at Manoa
Member
The Alliance
Master of Arts (M.A.)
Cognitive Psychology
University of Hawaii at Manoa
Doctor of Philosophy (PhD)
Cognitive Psychology
University of Hawaii at Manoa
Workshop: Actively Engaging Students in an Online Course
Bachelor of Science (BS)
Biopsychology
University of California
Santa Barbara
High school diploma
Honors
Punahou School
University Teaching
Cognitive Psychology
Online Teaching
Scientific Writing
Data Analysis
The heterocyst regulatory protein HetP and its homologs modulate heterocyst commitment in Anabaena sp. strain PCC 7120
Terminal commitment of differentiating cells is fundamental to multicellular life but remains the least characterized phase of development. Using Anabaena
a multicellular cyanobacterium that irreversibly commits 10% of cells to specialized nitrogen-fixing heterocysts
we report the identification of four genes that regulate commitment timing and efficacy in a cyanobacterium
including two that delay commitment: a unique finding across developmental model systems. Through protein–protein interactions
cell type-specific and -nonspecific expression patterns
and epistatic relationships
we present evidence that these four genes function together in a hierarchy to control correct timing of the commitment decision. This work illustrates the importance of Anabaena as a model system for studying the genetic underpinnings controlling the process of cellular differentiation.
The heterocyst regulatory protein HetP and its homologs modulate heterocyst commitment in Anabaena sp. strain PCC 7120
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