Roman Melnyk
- Courses1
- Reviews14
- School: University of Toronto
- Campus: St. George Campus
- Department: Biochemistry
- Email address: Join to see
- Phone: Join to see
-
Location:
Toronto, ON - Dates at University of Toronto: October 2013 - January 2020
- Office Hours: Join to see
N/A
Would take again: Yes
For Credit: Yes
0
0
Mandatory
Awesome
Professor Melnyk made a few relations that interested me between both Biochemistry and realworld examples.
N/A
Would take again: Yes
For Credit: Yes
0
0
Not Mandatory
Average
Professor Melnyk is a pretty good professor. I though the lectures were a little boring at times but he explained concepts well without rushing through anything.
Biography
University of Toronto St. George Campus - Biochemistry
Resume
2004
Collier lab
Toronto
Canada Area
Associate Professor
Department of Biochemistry
University of Toronto
The Hospital for Sick Children
Collier lab
Hospital for Sick Children
Research Institute at The Hospital for Sick Children
Scientist in Molecular Structure & Function Program
University of Toronto
Assistant Professor of Biochemistry
The Hospital for Sick Children
Sr. Research Scientist
Infectious Diseases\n• Co-led cross-functional and cross-site basic research team with a medicinal chemistry lead
consisting of ~40 MSc- and PhD-level biologists and chemists in lead optimization of small molecule candidates for treatment of HIV.\n• Core member of early development team responsible for review of internal pre-clinical and clinical HIV programs.\n• Led biology efforts on two lead identification programs (~10 scientists). Responsible for design and validation of novel HTS campaign
mechanism of action studies
and assay design.\nCardiovascular Diseases\n• Led two separate lead identification program teams (~10 scientists) in hypertension and atherosclerosis franchises. Responsible for design and follow-up of two HTS campaigns
mechanism-of-action studies
enzymology and biophysical analysis of small molecule-protein interactions.\n• Involved in identifying and validating potential novel hypertension targets from internal research efforts and external literature using siRNA approaches
mouse knockout phenotyping
small-molecule proof of concept studies.
Merck
Post Doc
• Mentor: R. John Collier
PhD \n• Research Focus: Molecular and structural determinants of anthrax toxin translocation; and
rational design of inhibitors of anthrax toxin translocation\n• Techniques: Electrophysiology – planar lipid bilayer and patch clamp
electron paramagnetic resonance
deuterium exchange mass spectrometry
tissue culture
molecular biophysics approaches: single-molecule studies•\n• First or co-author on 8 peer-reviewed publications in top journals including Science (1)
PNAS (3) and JBC (1)
Microbiology
1998
PhD
• Mentor: Charles M. Deber
PhD \n• Research Focus: Synthetic peptides as mimics and inhibitors of membrane protein folding & function; and
structural features of small multidrug resistant efflux pumps \n• Techniques: Solid-phase peptide synthesis
fluorescence resonance energy transfer
mass spectrometry
circular dichroism spectroscopy\n• First or co-author on 11 papers in peer-reviewed publications.
Biochemistry
1993
BSc
Biochemistry
1989
High School
Medicinal Chemistry
Infectious Diseases
Biochemistry
Biophysics
Protein Chemistry
High Throughput Screening
Peptide Synthesis
Assay Development
Clinical Development
Peptides
Fluorescence
Mass Spectrometry
Melnyk
Melnyk
The Hospital for Sick Children
Merck
University of Toronto
