Nathaniel V. Nucci
- Courses6
- Reviews15
- School: Rowan University
- Campus:
- Department: Physics
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Location:
201 Mullica Hill Rd
Glassboro, NJ - 08028 - Dates at Rowan University: January 2015 - January 2018
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Biography
Rowan University - Physics
Assistant Professor at Rowan University
Research
Nathaniel
Nucci
Philadelphia, Pennsylvania
I am an experimental physical biochemist with over a decade of experience in cutting-edge biochemical research. My background is broad, ranging from organismal biology, to molecular cloning, to protein biophysics. Through the course of my research career, I have gained extensive experience in method development. Currently, I am focused on the physical origins of protein and solvent dynamics in an effort to better understand the role of such motions in biological systems.
Long term research interests:
- The physical underpinnings of molecular recognition, particularly the motional, entropic contributions to binding events.
- The effects of nanoconfinement, such as those found inside the cell, on the structure, dynamics, and interactions of biological molecules.
Experience
University of Pennsylvania
Graduate Researcher
Dissertation on the hydrogen bonding behavior of water near small biological solutes and in nanconfined spaces. During my work with Professor Jane Vanderkooi, I used infrared and fluorescence spectroscopy in combination with molecular dynamics simulation and ab initio computation to examine the hydrogen bonding behavior of water near small biological molecules such as the catecholamine neurohormones and their precursors. One highlight of this work was the observation of vibrational coupling between solvent and solute through hydrogen bonds.
University of New Hampshire
Undergraduate and Graduate Researcher
Advisor: Professor Stacia A. Sower
Dr. Sower's group studies neuroendocrine evolutionary biology. My work focused on gonadotropin-releasing hormone receptor cloning and biology. I gained extensive experience in molecular biology, recombinant DNA methods, in situ hybridization and cytological techniques, and animal care practices.University of Pennsylvania School of Medicine
Postdoctoral research fellow
My work in research group of Professor A. Joshua Wand focuses on the dynamics of proteins and their hydration layer under nanoconfinement. We use high-resolution solution nuclear magnetic resonance (NMR) to measure the picosecond to nanosecond motions of proteins and solvent in an effort to better understand the physical principles which govern protein internal motions.
Rowan University
Assistant Professor
Nathaniel worked at Rowan University as a Assistant Professor
Education
University of Pennsylvania
Doctor of Philosophy (Ph.D.)
Biochemistry, Biophysics and Molecular Biology
Dissertation Title: On the Nature of Aqueous Solvation in Biological SystemsUniversity of Pennsylvania
Graduate Researcher
Dissertation on the hydrogen bonding behavior of water near small biological solutes and in nanconfined spaces. During my work with Professor Jane Vanderkooi, I used infrared and fluorescence spectroscopy in combination with molecular dynamics simulation and ab initio computation to examine the hydrogen bonding behavior of water near small biological molecules such as the catecholamine neurohormones and their precursors. One highlight of this work was the observation of vibrational coupling between solvent and solute through hydrogen bonds.University of New Hampshire
Bachelor of Science (BS)
Biochemistry and Molecular Biology
University of New Hampshire
Master of Science (MS)
Biochemistry and Molecular Biology
University of New Hampshire
Undergraduate and Graduate Researcher
Advisor: Professor Stacia A. Sower Dr. Sower's group studies neuroendocrine evolutionary biology. My work focused on gonadotropin-releasing hormone receptor cloning and biology. I gained extensive experience in molecular biology, recombinant DNA methods, in situ hybridization and cytological techniques, and animal care practices.
Publications
Site-resolved measurement of water-protein interactions by solution NMR
Nature Structural and Molecular Biology
Site-resolved measurement of water-protein interactions by solution NMR
Nature Structural and Molecular Biology
Mapping the Hydration Dynamics of Ubiquitin
J. Am. Chem Soc.
