Milica Radisic, University of Toronto Rate Professors

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University of Toronto St. George Campus - Engineering

University of Toronto
Associate Professor
Milica worked at University of Toronto as a Associate Professor
University of Toronto
Professor
Milica worked at University of Toronto as a Professor
University of Toronto
Assistant Professor
Milica worked at University of Toronto as a Assistant Professor

Biomaterial based cardiac tissue engineering and its applications
Biomedical Materials
Cardiovascular disease is a leading cause of death worldwide, necessitating the development of effective treatment strategies. A myocardial infarction involves the blockage of a coronary artery leading to depletion of nutrient and oxygen supply to cardiomyocytes and massive cell death in a region of the myocardium. Cardiac tissue engineering is the growth of functional cardiac tissue in vitro on biomaterial scaffolds for regenerative medicine application. This strategy relies on the optimization of the complex relationship between cell networks and biomaterial properties. In this review, we discuss important biomaterial properties for cardiac tissue engineering applications, such as elasticity, degradation, and induced host response, and their relationship to engineered cardiac cell environments. With these properties in mind, we also emphasize in vitro use of cardiac tissues for high-throughput drug screening and disease modelling.