Prairie View A&M University - Biology
Founding Executive Director, HDEART Consortium;
Professor Emeritus, UTMDACC Anderson;
Professor Emeritus, UTGSBS Houston
Higher Education
Lovell
Jones, PhD
Houston, Texas Area
Dr. Lovell Allan Jones received his doctorate in 1977 in the field of zoology with an emphasis in endocrinology and tumor biology from the University of California, Berkeley. During his training Dr. Jones was a National Institutes of Health (NIH) pre-doctoral trainee and a Ford Foundation Fellow at the UC Berkeley's Cancer Research Laboratory. After receiving his doctorate, Dr. Jones was a NIH Postdoctoral Fellow in the Reproductive Endocrinology Center at the University of California San Francisco (UCSF). His postdoctoral mentor was Dr. Pentti Siiteri. Before joining the Department of Gynecologic Oncology at University of Texas M. D. Anderson Cancer Center (UTMDACC) in 1980, Dr. Jones was an Instructor in the Departments of Physiology and Obstetrics, Gynecology & Reproductive Sciences at UCSF.
Until August 31, 2013, Dr. Jones was a Professor in the Department of Health Disparities Research as well as Professor of Biochemistry & Molecular Biology at the UTMDACC and Research Professor of Social Work, Graduate College of Social Work, University of Houston. He is the Founding Director of the Congressionally mandated Center for Research on Minority Health (CRMH), which evolved into the joint UH/UTMDACC Dorothy I. Height Center for Health Equity & Evaluation Research. At his retirement, the University of Texas System bestowed the title of Professor Emeritus in the Department of Health Disparities Research at UTMDACC.
Dr. Jones was awarded his second Professor Emeritus in April 2014 from the University of Texas Graduate School of Biomedical Sciences. This makes Dr. Jones one of the few African Americans (AA), if not the only AA to hold dual emeritus status in the University of Texas System. As one of his colleagues said, "Emeritus Squared."
Dr. Jones still hold Adjunct Faculty positions at Texas A& M School of Public Health, Texas A& M University Corpus Christi and Baylor College of Medicine and still writes for Houston Style Magazine on health issues
Research Faculty
A virtual faculty position that allows me to collaborate with faculty at TAMUCC, as well as others, to develop programs and research grants.
Professor Emeritus
In being appointed to Professor Emeritus at the University of Texas Graduate School of Biomedical Sciences, he become of the few, if not the only individual to hold dual Professor Emeritus status at two separate University of Texas institutions.
Professor Emeritus
The University of Texas Board of Regent bestowed on Dr. Jones, the honorific title of Professor Emeritus, becoming the first African American at the University of Texas MD Anderson Cancer Center and the first full Professor at any UT entity to be bestowed such a title.
Adjunct Professor
Serving as Executive Director of the HDEART Consortium, whose academic home is now at Texas A&M School of Public Health
Freelance Health Writer
Writing as the spirit hits me, opinion pieces on the state minority health and the factors that impact on the health and well being of people of color.
Ph.D.
Tumor Biology & Endocrinology
Worked on Endocrine Disruptors and Hormonal Carcinogenesis
Bachelor of Science (BS)
Biology/Biological Sciences, General
As a student I had a minor in World History, quite unusual for a biology major.
no degree
Zoology/Animal Biology
I was among the first African Americans to integrate LSU, especially in the sciences.
Environmental Health Perspectives
Abstract The neonatal mouse model has been a valuable tool in determining the long-term effects of early exposure to estrogenic agents in mammals. Using this model, we compared the effects of 2′,4′,6′-trichloro-4-biphenylol (OH-PCB-30) and 2′,3′,4′,5′-tetrachloro-4-biphenylol (OH-PCB-61) as prototype estrogenic hydroxylated PCBs (OH-PCBs) because they are reported to exhibit relatively high estrogenic activity both in vivo and in vitro. The purpose of this study was to examine the relationship between estrogenicity and carcinogenicity of OH-PCB congeners. The OH-PCBs were tested individually and in combination to determine whether effects of combined OH-PCBs differed from those of these OH-PCBs alone. We evaluated the long-term effects of neonatal exposure to OH-PCBs with treatment doses that were based on the reported binding affinity of specific OH-PCB congeners to estrogen receptor α. BALB/cCrgl female mice were treated within 16 hr after birth by subcutaneous injections every 24 hr, for 5 days. The mice treated with OH-PCB-30 (200 μg/day) or 17β-estradiol (5 μg/day) showed similar increased incidences of cervicovaginal (CV) tract carcinomas (43% and 47%, respectively). In addition, when mice were treated with OH-PCBs as a mixture, a change in the type of CV tract tumor was observed, shifting from predominantly squamous cell carcinomas to adenosquamous cell carcinoma. From our results, we conclude that the individual OH-PCBs tested were estrogenic and tumorigenic in mice when exposed during development of the reproductive tract. These data support the hypothesis that mixtures may act differently and unexpectedly than do individual compounds.
Environmental Health Perspectives
Abstract The neonatal mouse model has been a valuable tool in determining the long-term effects of early exposure to estrogenic agents in mammals. Using this model, we compared the effects of 2′,4′,6′-trichloro-4-biphenylol (OH-PCB-30) and 2′,3′,4′,5′-tetrachloro-4-biphenylol (OH-PCB-61) as prototype estrogenic hydroxylated PCBs (OH-PCBs) because they are reported to exhibit relatively high estrogenic activity both in vivo and in vitro. The purpose of this study was to examine the relationship between estrogenicity and carcinogenicity of OH-PCB congeners. The OH-PCBs were tested individually and in combination to determine whether effects of combined OH-PCBs differed from those of these OH-PCBs alone. We evaluated the long-term effects of neonatal exposure to OH-PCBs with treatment doses that were based on the reported binding affinity of specific OH-PCB congeners to estrogen receptor α. BALB/cCrgl female mice were treated within 16 hr after birth by subcutaneous injections every 24 hr, for 5 days. The mice treated with OH-PCB-30 (200 μg/day) or 17β-estradiol (5 μg/day) showed similar increased incidences of cervicovaginal (CV) tract carcinomas (43% and 47%, respectively). In addition, when mice were treated with OH-PCBs as a mixture, a change in the type of CV tract tumor was observed, shifting from predominantly squamous cell carcinomas to adenosquamous cell carcinoma. From our results, we conclude that the individual OH-PCBs tested were estrogenic and tumorigenic in mice when exposed during development of the reproductive tract. These data support the hypothesis that mixtures may act differently and unexpectedly than do individual compounds.
Clinical Cancer Research 7: 2984-2997, 2001.
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