Kevin Burgess
- Courses7
- Reviews19
- School: Texas A&M University
- Campus: College Station
- Department: Chemistry
- Email address: Join to see
- Phone: Join to see
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Location:
College Station, TX - Dates at Texas A&M University: August 2004 - January 2020
- Office Hours: Join to see
N/A
Would take again: Yes
For Credit: Yes
0
0
Mandatory
Average
Tests are pages copied from the workbook. You only need to purchase the workbooks.
N/A
Would take again: Yes
For Credit: Yes
0
0
Good
Kevin Burgess can be very boring and not very helpful when it comes to explaining the workbook that contains, the final exam. The workbook is literally the final exam. Still, the final is also not cumulative and he doesn't do synthesis problems!
N/A
Would take again: No
For Credit: Yes
0
0
Mandatory
Poor
AVOID ALL COSTS THIS CLASS! He utilizes a manual he developed to accompany his presentations. Giving half of the responses is incorrect. He doesn't necessarily teach, but he just responds and expects you to understand how to do it. As his test progresses, A Plus tutoring won't assist you! Every day in the school there are quizzes!
N/A
Would take again: Yes
For Credit: Yes
0
0
Mandatory
Awesome
Prof. Burgess is very passionate and he really helped me love organic chemistry. I feel like the reason why some students struggled is because this is a flipped classroom model. I was always lost in class, but I found that as long as I work hard a little every day, I'll be able to understand and excel. He's an amazing prof!
Biography
Texas A&M University College Station - Chemistry
President at ByInquisition Press
Research
Kevin
Burgess
Bryan/College Station, Texas Area
I worked with Professor A. R Katrizky (MSc; University of East Anglia), Lord Lewis (PhD; Cambridge University) and Professor B. M. Trost (postdoctoral, U. Wisconsin). After, I spent two years at University of Cambridge, UK, funded by a research fellowship from Girton College to promote independent research, then moved to Rice University as an assistant professor. In 1992, I joined to Texas A & M where I am now Rachal Professor of Chemistry.
At present, my publications include over 250 papers, 4 patents, and two books. H-index 49 as of May, 2010.
Our group focuses on synthesis and synthetic methodology to tackle problems in medicinal chemistry and biotechnology. Essentially, the current active projects are:
• syntheses, mediated by organometallic catalysts, of privileged chirons found in natural products;
• syntheses of dipeptide mimics;
• use of a special method to construct combinatorial libraries of molecules designed to disrupt or mimic protein-protein interactions; and,
• syntheses of fluorescent through-bond-energy-transfer cassettes to facilitate observation of protein-protein interactions in cells.
Specialties: medicinal chemistry, combinatorial chemistry, organic syntheses, asymmetric catalysis, and fluorescent dyes.
Experience
ByInquisition Press
President
Author of "Organic Chemistry By Inquisition" available with molecular models from www.byinquisition.org
Rice University
Assistant Professor
Kevin worked at Rice University as a Assistant Professor
Texas A&M University
Rachal Professor of Organic Chemistry
Homogenous catalysis, combinatorial chemistry, fluorescent dyes, medicinal chemistry, and peptide mimic compounds.
In addition, I am involved in legal consulting work, and have served as an expert witness on several cases relating to pharmaceuticals.Chemistry and Industry
Co-Author of "Highlights"
Highlights is a monthly review of recent developments in the chemical literature.
Texas A & M University, Small Molecule PPI Mimics LLC, and By Inquisition Press
Professor
Kevin worked at Texas A & M University, Small Molecule PPI Mimics LLC, and By Inquisition Press as a Professor
Education
University of Cambridge
PhD
Organometallics
Under supervision of Lord Lewis.Texas A&M University
Rachal Professor of Organic Chemistry
Homogenous catalysis, combinatorial chemistry, fluorescent dyes, medicinal chemistry, and peptide mimic compounds. In addition, I am involved in legal consulting work, and have served as an expert witness on several cases relating to pharmaceuticals.
Publications
A Chemoselective Route to β-Enamino Esters and Thioesters
Organic Letters
Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein–protein interface mimics.
A Chemoselective Route to β-Enamino Esters and Thioesters
Organic Letters
Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein–protein interface mimics.
Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)
Org. Biomol. Chem./RSC Publishing
This article describes a protocol for fitting each member of an array of accessible scaffold conformations on secondary structures. The protocol involves: (i) use quenched molecular dynamics (QMD) to generate an ensemble consisting of hundreds of accessible, low energy conformers of the mimics; (ii) representation of each of these as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; (iii) similar representation of each combination of three side-chains in each ideal secondary structure as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; and, (iv) overlay Cα and Cβ coordinates of all the conformers on all the sets of side-chain “triads” in the ideal secondary structures and express the goodness of fit in terms of root mean squared deviation (RMSD, Å) for each overlay. We refer to this process as Exploring Key Orientations on Secondary structures (EKOS).
A Chemoselective Route to β-Enamino Esters and Thioesters
Organic Letters
Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein–protein interface mimics.
Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)
Org. Biomol. Chem./RSC Publishing
This article describes a protocol for fitting each member of an array of accessible scaffold conformations on secondary structures. The protocol involves: (i) use quenched molecular dynamics (QMD) to generate an ensemble consisting of hundreds of accessible, low energy conformers of the mimics; (ii) representation of each of these as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; (iii) similar representation of each combination of three side-chains in each ideal secondary structure as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; and, (iv) overlay Cα and Cβ coordinates of all the conformers on all the sets of side-chain “triads” in the ideal secondary structures and express the goodness of fit in terms of root mean squared deviation (RMSD, Å) for each overlay. We refer to this process as Exploring Key Orientations on Secondary structures (EKOS).
Expanding the Scope of Oligo-pyrrolinone−Pyrrolidines as Protein−Protein Interface Mimics
The Journal of Organic Chemistry
Oligo-pyrrolinone–pyrrolidines (generic structure 1) have the potential to interfere with protein–protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains corresponding to genetically encoded proteins. This paper describes expansion of the synthetic scope of 1, the difficulties encountered in this process, particularly issues with epimerization and slow coupling rates, and methods to overcome them. Finally, spectroscopic and physicochemical properties as well as proteolytic stabilities of molecules in this series were measured; these data highlight the suitability of oligo-pyrrolinone–pyrrolidines for the development of pharmacological probes or pharmaceutical leads.
A Chemoselective Route to β-Enamino Esters and Thioesters
Organic Letters
Conditions were developed for syntheses of β-enamino esters, thioesters, and amides. These reactions involve hydroxybenzotriazole derivatives in buffered media. Illustrative syntheses of some heterocyclic systems are given, including some related to protein–protein interface mimics.
Evaluating minimalist mimics by exploring key orientations on secondary structures (EKOS)
Org. Biomol. Chem./RSC Publishing
This article describes a protocol for fitting each member of an array of accessible scaffold conformations on secondary structures. The protocol involves: (i) use quenched molecular dynamics (QMD) to generate an ensemble consisting of hundreds of accessible, low energy conformers of the mimics; (ii) representation of each of these as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; (iii) similar representation of each combination of three side-chains in each ideal secondary structure as a set of Cα and Cβ coordinates corresponding to three amino acid side-chains displayed by the scaffolds; and, (iv) overlay Cα and Cβ coordinates of all the conformers on all the sets of side-chain “triads” in the ideal secondary structures and express the goodness of fit in terms of root mean squared deviation (RMSD, Å) for each overlay. We refer to this process as Exploring Key Orientations on Secondary structures (EKOS).
Expanding the Scope of Oligo-pyrrolinone−Pyrrolidines as Protein−Protein Interface Mimics
The Journal of Organic Chemistry
Oligo-pyrrolinone–pyrrolidines (generic structure 1) have the potential to interfere with protein–protein interactions (PPIs), but to reduce this to practice it is necessary to be able to synthesize these structures with a variety of different side chains corresponding to genetically encoded proteins. This paper describes expansion of the synthetic scope of 1, the difficulties encountered in this process, particularly issues with epimerization and slow coupling rates, and methods to overcome them. Finally, spectroscopic and physicochemical properties as well as proteolytic stabilities of molecules in this series were measured; these data highlight the suitability of oligo-pyrrolinone–pyrrolidines for the development of pharmacological probes or pharmaceutical leads.
Extended Piperidine–Piperidinone Protein Interface Mimics
The Journal of Organic Chemistry
Minimalist structures, H and I, were designed as protein interface mimics. Attributes of these chemotypes are (i) greater rigidity than conventional peptides, (ii) chiral and nonplanar heterocyclic backbones that are less prone to the hydrophobic aggregation effects, and (iii) potential to be prepared with a variety of side chains corresponding to natural amino acids. Intermediates, however, in the oligo(pyrrolidinone-piperidine)s H syntheses were vulnerable to epimerization. The origins of this epimerization were determined, then the study was focused on oligo(piperidinone–piperidine) compounds I. Mimics I were prepared via iterative couplings; a penta(piperidinone–piperidine) was prepared in this way. A series of lower homologues of this pentamer were crystallized and studied (single crystal X-ray), and four of them were used in a circular dichroism (CD) study. Thus, an estimate of 36 Å for the N-to-C distance of a typical conformation of the penta(piperidinone–piperidine) was made. CD spectra of four progressively longer oligomers allowed assignment of elipticity changes around 300 nm that can be attributed to increased conformational ordering of the longer oligomers in solution.
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Texas A&M University - Texas A&m University
