Saratov State Socio-Economic University

Research Assistant

Conducted experimental studies in clinical populations (schizophrenia patients) on constitutional biomarkers of risks for developing paranoid schizophrenia. The Research group was funded with Grant from the Ministry of Education and Science of Russian Federation (Principal Investigator – Dr.Alexander Zaichenko, MD).

University of Saskatchewan

Instructor

My primary role in this position is to coordinate, supervise and teach laboratory components of the undergraduate courses offered in the Biomedical Sciences primarily in the areas of Physiology and Pharmacology.

Saskatchewan Neuroscience Network

The Brain Bee (modelled after Spelling Bee) competition tests the high school students' knowledge in various topics of neuroscience, and motivates the students to pursue neuroscience and health science related careers.

The winner of the regional Brain Bee represents the province in the national and international Brain Bee Championships.

http://brainbee.ca/

Saskatchewan Young Professionals & Entrepreneurs (SYPE)

Planned and organized networking events for SYPE members

“Biometric indices of constitutional risks for developing paranoid schizophrenia in male patients

Saratov Journal of Medical Scientific Research: Vol. 5 - № 3. P. 384-389

“Biometric indices of constitutional risks for developing paranoid schizophrenia in male patients

Saratov Journal of Medical Scientific Research: Vol. 5 - № 3. P. 384-389

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus

Neuropharmacology 2

“Biometric indices of constitutional risks for developing paranoid schizophrenia in male patients

Saratov Journal of Medical Scientific Research: Vol. 5 - № 3. P. 384-389

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus

Neuropharmacology 2

Cyclical Corticosterone Administration Sensitizes Depression-Like Behavior in Rats

Neuroscience Letters

Because stress is a significant risk factor for depression, many animal models of depression employ chronic stress as a precipitating event. However, almost without exception, stress-induced animal models of depression focus on a single bout of depression and therefore, they do not provide any means to understand the typical cycling of mood observed in most patients with depression. Here we assessed whether repeated cycles of exposure to the stress hormone corticosterone would sensitize depression-like behavior. Rats were treated with corticosterone (CORT; 20 or 40 mg/kg) or vehicle for two cycles (21 days each), followed by a 21-day recovery period. Depression-like behavior was assessed via repeated forced swim tests (FSTs) in the middle and at the end of each CORT treatment and at the end of each recovery period. Our results showed that CORT administration for two cycles produces increasingly greater effects on depression-like behavior and a decrease in recovery between cycles. Potential confounding effects of body weight and repetitive behavioral testing are considered in the interpretation of these effects. Our approach of using more than one cycle of CORT exposure provides strong face validity as it mimics several aspects of human depression. The use of multiple cycles of CORT exposure may provide a means to study the episode recurrence seen in more than 70% of patients with depression.

“Biometric indices of constitutional risks for developing paranoid schizophrenia in male patients

Saratov Journal of Medical Scientific Research: Vol. 5 - № 3. P. 384-389

The progressive development of depression-like behavior in corticosterone-treated rats is paralleled by slowed granule cell maturation and decreased reelin expression in the adult dentate gyrus

Neuropharmacology 2

Cyclical Corticosterone Administration Sensitizes Depression-Like Behavior in Rats

Neuroscience Letters

Because stress is a significant risk factor for depression, many animal models of depression employ chronic stress as a precipitating event. However, almost without exception, stress-induced animal models of depression focus on a single bout of depression and therefore, they do not provide any means to understand the typical cycling of mood observed in most patients with depression. Here we assessed whether repeated cycles of exposure to the stress hormone corticosterone would sensitize depression-like behavior. Rats were treated with corticosterone (CORT; 20 or 40 mg/kg) or vehicle for two cycles (21 days each), followed by a 21-day recovery period. Depression-like behavior was assessed via repeated forced swim tests (FSTs) in the middle and at the end of each CORT treatment and at the end of each recovery period. Our results showed that CORT administration for two cycles produces increasingly greater effects on depression-like behavior and a decrease in recovery between cycles. Potential confounding effects of body weight and repetitive behavioral testing are considered in the interpretation of these effects. Our approach of using more than one cycle of CORT exposure provides strong face validity as it mimics several aspects of human depression. The use of multiple cycles of CORT exposure may provide a means to study the episode recurrence seen in more than 70% of patients with depression.

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Neuroscience Network

Organizer of community outreach events (Brain Bee, Brain Blast, Brain Day).

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Neuroscience Network

Organizer of community outreach events (Brain Bee, Brain Blast, Brain Day).

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Neuroscience Network

Organizer of community outreach events (Brain Bee, Brain Blast, Brain Day).

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Neuroscience Network

Organizer of community outreach events (Brain Bee, Brain Blast, Brain Day).

Saskatchewan Young Professionals and Entrepreneurs (SYPE)

Board Member

Saskatchewan Neuroscience Network

Organizer of community outreach events (Brain Bee, Brain Blast, Brain Day).