James W. Hicks is a/an Professor in the University Of California department at University Of California
University of California Irvine - Biology
PhD
Biomedical Sciences--Physiology
The University of New Mexico School of Medicine
MS
Biology
The University of New Mexico
University of California
Irvine
BA
Biology
California State University-Fullerton
Home - Exercise Medicine and Sport Sciences Initiative
The Exercise Medicine and Sport Sciences Initiative (EMSSI) is a newly formed
unique multidisciplinary program that promotes scholarly activities and innovative discoveries in all fields associated with movement
including exercise and sport sciences
exercise medicine and rehabilitation.
Exercise Medicine and Sport Sciences Initiative
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Terrestrial locomotion does not constrain venous return in the American alligator
Alligator mississippiensis
The effects of treadmill exercise on components of the cardiovascular (heart rate
mean arterial blood pressure
central venous pressure
venous return) and respiratory (minute ventilation
tidal volume
breathing frequency
rate of oxygen consumption
rate of carbon dioxide production) systems and on intra-abdominal pressure were measured in the American alligator
Alligator\nmississippiensis
at 30°C. Alligators show speed-dependent increases in tidal volume and minute ventilation
demonstrating that the inhibition of ventilation during locomotion that is present in some varanid and iguanid lizards was not present in alligators. Exercise significantly\nincreases intra-abdominal pressure; however
concomitant elevations in central venous pressure acted to increase the transmural pressure of the post caval vein and thus increased venous return. Therefore
despite elevated intraabdominal pressure
venous return was not limited during exercise in alligators
as was the case in Varanus exanthematicus and Iguana iguana. Respiratory cycle\nvariations in intra-abdominal pressure
central venous pressure and venous return indicate that
at high tidal volumes
inspiration causes a net reduction in venous return during active ventilation and thus may act to limit venous return during exercise. These results suggest that
while tonically elevated intra-abdominal pressure induced by exercise does not inhibit venous return
phasic\nfluctuations during each breath cycle may contribute to venous flow limitation during exercise.
Terrestrial locomotion does not constrain venous return in the American alligator
Alligator mississippiensis
Over a decade has passed since Powell et al. (Respir Physiol 112:123–134
1998) described and defined the time domains of the hypoxic ventilatory response (HVR) in adult mammals. These time domains
however
have yet to receive much attention in other vertebrate groups. The initial
acute HVR of fish
amphibians and reptiles serves to minimize the imbalance between oxygen supply and demand. If the hypoxia is sustained
a suite of secondary adjustments occur giving rise to a more long-term balance (acclimatization) that allows the behaviors of normal life. These secondary responses can change over time as a function of the nature of the stimulus (the pattern and intensity of the hypoxic exposure). To add to the complexity of this process
hypoxia can also lead to metabolic suppression (the hypoxic metabolic response) and the magnitude of this is also time dependent. Unlike the original review of Powell et al. (Respir Physiol 112:123–134
1998) that only considered the HVR in adult animals
we also consider relevant developmental time points where information is available. Finally
in amphibians and reptiles with incompletely divided hearts the magnitude of the ventilatory response will be modulated by hypoxia-induced changes in intra-cardiac shunting that also improve the match between O2 supply and demand
and these too change in a time-dependent fashion. While the current literature on this topic is reviewed here
it is noted that this area has received little attention. We attempt to redefine time domains in a more ‘holistic’ fashion that better accommodates research on ectotherms. If we are to distinguish between the genetic
developmental and environmental influences underlying the various ventilatory responses to hypoxia
however
we must design future experiments with time domains in mind.
Time domains of the hypoxic ventilatory response in ectothermic vertebrates
Varanus exanthematicus demonstrates constrained skeletal muscle plasticity in response to joint immobilization
Most sports have a certain degree of danger associated with them
due to flying objects and bodies colliding at high speeds. Soccer and water polo are particularly dangerous for one of the most important parts of the human body; the head. Head injury in these sports may stem from contact with the goal posts
other players
the side walls (in water polo) or the ground (in soccer). However
these sports bear a unique danger to the head when compared with other competitive sports due to the nature of ball interaction. Soccer is the only competitive sport that involves and condones purposeful head contact with the ball
and water polo is one of the only sports that involves ball flight almost exclusively in a plane parallel with head altitude. As a consequence of engaging in these sports
risk of head injury
especially concussions due to such ball interactions
is dramatically increased. In 2009 alone
hospitals reported 24
184 cases of soccer head injury
and 28
716 cases of water polo head injury (American Association of Neurological Surgeons - AANS). Furthermore
head trauma in these cases can cause a plethora of disabilities. These can range from loss of motor function to complete paralysis to death in the most severe cases. \n\nThe existence of these serious injuries make it critical to reduce the amount of risk taken when participating in these sports. Specifically
our team is searching for methods of minimizing the amount of impact force experienced by the head by ball contact. Interestingly
there is little to no precedent for tests on ball specifications and their implications on impact forces in these two sports.\n\nhttps://lnkd.in/b3KTvEc
James
Hicks
Scripps Institution of Oceanography--Physiological Research Laboratory
The Max-Planck Institute for Experimental Medicine
University of California Irvine
Creighton University
UC Irvine
Exercise Medicine and Sport Sciences Initiative UC Irvine
UC Irvine
University of California Irvine
Irvine
CA
I believe that it is important to articulate the power of comparative and evolutionary physiology and to point out that these approaches are not mutually exclusive to biomedical sciences. Comparative physiology
at its most basic level
seeks to discover how animals work
and
most importantly
why animals work the way they do. These two seemingly straightforward questions have far-reaching implications and require a variety of investigative approaches. The comparative physiologist is challenged to determine the details of physiological mechanisms while simultaneously gaining insights into ultimate causation
i.e. the evolutionary or adaptive significance of a physiological process or trait. This manifold focus on proximal mechanism and ultimate causality requires that comparative and evolutionary physiologists bring to their investigations a diversity of analytical approaches and to effectively integrate molecular
cellular
organismal
morphological
biomechanical
biophysical
ecological and evolutionary information.
Professor
La Jolla
CA
Research with Professor Fred White.
Postdoctoral Fellow
Scripps Institution of Oceanography--Physiological Research Laboratory
Irvine
CA
Department Chair-Ecology and Evolutionary Biology
UC Irvine
Gottingen
Germany
Research in comparative aspects of circulation and respiration. Worked with Professor Norbert Heisler and Dr. Atsushi Ishimatsu
Postdoctoral Fellow
The Max-Planck Institute for Experimental Medicine
As the Institutional Official
provides oversight of regulatory compliance committees at UCI; including the IACUC
IRBs
hSCRO
COI and IBC. Responsible for identifying strategies to improve institutional support for faculty research
including development of interdisciplinary and large-scale research funding opportunities and coordination of core research facilities. In addition
serves as a liaison for local and regional economic development opportunities and technology transfer.
University of California Irvine
Exercise Medicine and Sport Sciences Initiative UC Irvine
University of California Irvine
The Exercise Medicine and Sport Sciences Initiative (EMSSI) at UC Irvine is a newly formed
unique multidisciplinary program that promotes scholarly activities and innovative discoveries in all fields associated with movement
including exercise and sport sciences
exercise medicine and rehabilitation. The Initiative is dedicated to enhancing human health and wellness through undergraduate and graduate teaching
basic and translational research
development of innovative technologies
service to the community
and clinical activities.
Director
Omaha
Nebraska
Research and education. Taught cardiovascular physiology at the Creighton School of Medicine
and cardiopulmonary lectures at the Creighton School of Dentistry.
Professor
Creighton University
Awarded to faculty above Professor Step V who are respected scholars
and
who
at some point in their careers
have made outstanding contributions of service to the University of California. An outstanding contribution is not defined simply as having served on a large number of Senate Committees
although such may be one of the factors. It is defined as service which leads to the betterment of the academic and/or personal lives of large segments of the University community.
UC Irvine Academic Senate
Honorary Doctorate-Science and Technology Aarhus University Denmark
Professor James W. Hicks is a highly significant researcher within the field of comparative physiology. During his career he has worked broadly with respiration and circulatory physiology
and in particular he has contributed new knowledge regarding physiological responses to increased metabolism and the influence of gravity on the circulatory system. Professor James W. Hicks has made a fundamental contribution to our understanding of the function of the heart in reptiles
and his scientific work is a shining example of the way in which integrative studies at many levels of biological organisation generate understanding of how and why animals function as they do.\n\nJames W. Hicks has published almost 100 articles
a number of which have been printed in high-profile journals such as Science
Nature and PNAS. He has played a leading role in a great number of academic forums and been particularly active in the work involved in strengthening cross-disciplinary
rewarding interaction between comparative physiology and the more clinical physiology practised by medical science.\n\nIn addition to being an excellent researcher
James W. Hicks is a brilliant lecturer and a fantastic communicator who is capable of providing simple but accurate explanations of complicated issues. He is an extremely active communicator
and has made lengthy contributions to a variety of programmes produced by the BBC
Discovery Channel and National Geographic.\n\nIn 1985 James W. Hicks visited Aarhus University for the first time
since when he has enjoyed close contact with the zoo-physiology group at the university. This has resulted in a great number of joint scientific publications as well as exchanges of students and postdocs.
Aarhus University
Aarhus Denmark
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