James Hicks

 JamesW. Hicks

James W. Hicks

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Biography

James W. Hicks is a/an Professor in the University Of California department at University Of California

University of California Irvine - Biology


Resume

  • 1979

    PhD

    Biomedical Sciences--Physiology

    The University of New Mexico School of Medicine

  • 1977

    MS

    Biology

    The University of New Mexico

  • 1972

    University of California

    Irvine

    BA

    Biology

    California State University-Fullerton

  • Home - Exercise Medicine and Sport Sciences Initiative

    The Exercise Medicine and Sport Sciences Initiative (EMSSI) is a newly formed

    unique multidisciplinary program that promotes scholarly activities and innovative discoveries in all fields associated with movement

    including exercise and sport sciences

    exercise medicine and rehabilitation.

    Exercise Medicine and Sport Sciences Initiative

    Experimentation

    Lifesciences

    Research

    Animal Models

    Higher Education

    Western Blotting

    Physiology

    Experimental Design

    PCR

    In Vivo

    Teaching

    Scientific Writing

    Cell Biology

    Science

    Cell Culture

    Grant Writing

    Awesomeness

    Life Sciences

    Statistics

    University Teaching

    Terrestrial locomotion does not constrain venous return in the American alligator

    Alligator mississippiensis

    The effects of treadmill exercise on components of the cardiovascular (heart rate

    mean arterial blood pressure

    central venous pressure

    venous return) and respiratory (minute ventilation

    tidal volume

    breathing frequency

    rate of oxygen consumption

    rate of carbon dioxide production) systems and on intra-abdominal pressure were measured in the American alligator

    Alligator\nmississippiensis

    at 30°C. Alligators show speed-dependent increases in tidal volume and minute ventilation

    demonstrating that the inhibition of ventilation during locomotion that is present in some varanid and iguanid lizards was not present in alligators. Exercise significantly\nincreases intra-abdominal pressure; however

    concomitant elevations in central venous pressure acted to increase the transmural pressure of the post caval vein and thus increased venous return. Therefore

    despite elevated intraabdominal pressure

    venous return was not limited during exercise in alligators

    as was the case in Varanus exanthematicus and Iguana iguana. Respiratory cycle\nvariations in intra-abdominal pressure

    central venous pressure and venous return indicate that

    at high tidal volumes

    inspiration causes a net reduction in venous return during active ventilation and thus may act to limit venous return during exercise. These results suggest that

    while tonically elevated intra-abdominal pressure induced by exercise does not inhibit venous return

    phasic\nfluctuations during each breath cycle may contribute to venous flow limitation during exercise.

    Terrestrial locomotion does not constrain venous return in the American alligator

    Alligator mississippiensis

    Over a decade has passed since Powell et al. (Respir Physiol 112:123–134

    1998) described and defined the time domains of the hypoxic ventilatory response (HVR) in adult mammals. These time domains

    however

    have yet to receive much attention in other vertebrate groups. The initial

    acute HVR of fish

    amphibians and reptiles serves to minimize the imbalance between oxygen supply and demand. If the hypoxia is sustained

    a suite of secondary adjustments occur giving rise to a more long-term balance (acclimatization) that allows the behaviors of normal life. These secondary responses can change over time as a function of the nature of the stimulus (the pattern and intensity of the hypoxic exposure). To add to the complexity of this process

    hypoxia can also lead to metabolic suppression (the hypoxic metabolic response) and the magnitude of this is also time dependent. Unlike the original review of Powell et al. (Respir Physiol 112:123–134

    1998) that only considered the HVR in adult animals

    we also consider relevant developmental time points where information is available. Finally

    in amphibians and reptiles with incompletely divided hearts the magnitude of the ventilatory response will be modulated by hypoxia-induced changes in intra-cardiac shunting that also improve the match between O2 supply and demand

    and these too change in a time-dependent fashion. While the current literature on this topic is reviewed here

    it is noted that this area has received little attention. We attempt to redefine time domains in a more ‘holistic’ fashion that better accommodates research on ectotherms. If we are to distinguish between the genetic

    developmental and environmental influences underlying the various ventilatory responses to hypoxia

    however

    we must design future experiments with time domains in mind.

    Time domains of the hypoxic ventilatory response in ectothermic vertebrates

    Varanus exanthematicus demonstrates constrained skeletal muscle plasticity in response to joint immobilization

    Most sports have a certain degree of danger associated with them

    due to flying objects and bodies colliding at high speeds. Soccer and water polo are particularly dangerous for one of the most important parts of the human body; the head. Head injury in these sports may stem from contact with the goal posts

    other players

    the side walls (in water polo) or the ground (in soccer). However

    these sports bear a unique danger to the head when compared with other competitive sports due to the nature of ball interaction. Soccer is the only competitive sport that involves and condones purposeful head contact with the ball

    and water polo is one of the only sports that involves ball flight almost exclusively in a plane parallel with head altitude. As a consequence of engaging in these sports

    risk of head injury

    especially concussions due to such ball interactions

    is dramatically increased. In 2009 alone

    hospitals reported 24

    184 cases of soccer head injury

    and 28

    716 cases of water polo head injury (American Association of Neurological Surgeons - AANS). Furthermore

    head trauma in these cases can cause a plethora of disabilities. These can range from loss of motor function to complete paralysis to death in the most severe cases. \n\nThe existence of these serious injuries make it critical to reduce the amount of risk taken when participating in these sports. Specifically

    our team is searching for methods of minimizing the amount of impact force experienced by the head by ball contact. Interestingly

    there is little to no precedent for tests on ball specifications and their implications on impact forces in these two sports.\n\nhttps://lnkd.in/b3KTvEc

    James

    Hicks

    Scripps Institution of Oceanography--Physiological Research Laboratory

    The Max-Planck Institute for Experimental Medicine

    University of California Irvine

    Creighton University

    UC Irvine

    Exercise Medicine and Sport Sciences Initiative UC Irvine

    UC Irvine

    University of California Irvine

    Irvine

    CA

    I believe that it is important to articulate the power of comparative and evolutionary physiology and to point out that these approaches are not mutually exclusive to biomedical sciences. Comparative physiology

    at its most basic level

    seeks to discover how animals work

    and

    most importantly

    why animals work the way they do. These two seemingly straightforward questions have far-reaching implications and require a variety of investigative approaches. The comparative physiologist is challenged to determine the details of physiological mechanisms while simultaneously gaining insights into ultimate causation

    i.e. the evolutionary or adaptive significance of a physiological process or trait. This manifold focus on proximal mechanism and ultimate causality requires that comparative and evolutionary physiologists bring to their investigations a diversity of analytical approaches and to effectively integrate molecular

    cellular

    organismal

    morphological

    biomechanical

    biophysical

    ecological and evolutionary information.

    Professor

    La Jolla

    CA

    Research with Professor Fred White.

    Postdoctoral Fellow

    Scripps Institution of Oceanography--Physiological Research Laboratory

    Irvine

    CA

    Department Chair-Ecology and Evolutionary Biology

    UC Irvine

    Gottingen

    Germany

    Research in comparative aspects of circulation and respiration. Worked with Professor Norbert Heisler and Dr. Atsushi Ishimatsu

    Postdoctoral Fellow

    The Max-Planck Institute for Experimental Medicine

    As the Institutional Official

    provides oversight of regulatory compliance committees at UCI; including the IACUC

    IRBs

    hSCRO

    COI and IBC. Responsible for identifying strategies to improve institutional support for faculty research

    including development of interdisciplinary and large-scale research funding opportunities and coordination of core research facilities. In addition

    serves as a liaison for local and regional economic development opportunities and technology transfer.

    University of California Irvine

    Exercise Medicine and Sport Sciences Initiative UC Irvine

    University of California Irvine

    The Exercise Medicine and Sport Sciences Initiative (EMSSI) at UC Irvine is a newly formed

    unique multidisciplinary program that promotes scholarly activities and innovative discoveries in all fields associated with movement

    including exercise and sport sciences

    exercise medicine and rehabilitation. The Initiative is dedicated to enhancing human health and wellness through undergraduate and graduate teaching

    basic and translational research

    development of innovative technologies

    service to the community

    and clinical activities.

    Director

    Omaha

    Nebraska

    Research and education. Taught cardiovascular physiology at the Creighton School of Medicine

    and cardiopulmonary lectures at the Creighton School of Dentistry.

    Professor

    Creighton University

    Awarded to faculty above Professor Step V who are respected scholars

    and

    who

    at some point in their careers

    have made outstanding contributions of service to the University of California. An outstanding contribution is not defined simply as having served on a large number of Senate Committees

    although such may be one of the factors. It is defined as service which leads to the betterment of the academic and/or personal lives of large segments of the University community.

    UC Irvine Academic Senate

    Honorary Doctorate-Science and Technology Aarhus University Denmark

    Professor James W. Hicks is a highly significant researcher within the field of comparative physiology. During his career he has worked broadly with respiration and circulatory physiology

    and in particular he has contributed new knowledge regarding physiological responses to increased metabolism and the influence of gravity on the circulatory system. Professor James W. Hicks has made a fundamental contribution to our understanding of the function of the heart in reptiles

    and his scientific work is a shining example of the way in which integrative studies at many levels of biological organisation generate understanding of how and why animals function as they do.\n\nJames W. Hicks has published almost 100 articles

    a number of which have been printed in high-profile journals such as Science

    Nature and PNAS. He has played a leading role in a great number of academic forums and been particularly active in the work involved in strengthening cross-disciplinary

    rewarding interaction between comparative physiology and the more clinical physiology practised by medical science.\n\nIn addition to being an excellent researcher

    James W. Hicks is a brilliant lecturer and a fantastic communicator who is capable of providing simple but accurate explanations of complicated issues. He is an extremely active communicator

    and has made lengthy contributions to a variety of programmes produced by the BBC

    Discovery Channel and National Geographic.\n\nIn 1985 James W. Hicks visited Aarhus University for the first time

    since when he has enjoyed close contact with the zoo-physiology group at the university. This has resulted in a great number of joint scientific publications as well as exchanges of students and postdocs.

    Aarhus University

    Aarhus Denmark

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