University of Colorado Health Sciences Center

Graduate Researcher

• Funded through NIH Countermeasures Against Chemical Threats/ CounterACT to investigate respiratory injury following mustard analog gas inhalation (2-chlorethyl ethyl sulfide, CEES)
• Screening antioxidant therapeutics as rescue agents for CEES exposure
• Communicated pre-clinical findings in manuscripts, presentations and posters

University of Colorado Denver

Professional Research Assistant

• Personnel and general lab management
• Screening potential therapeutics for schizophrenia in pre-clinical models
• Outcomes include 3 manuscripts as well as 1 invited presentation

Front Range Community College

Adjunct Faculty

• Courses taught include General (majors) Biology, Non-Majors Biology, and Environmental Science
• Course development for Introductory Environmental Science
• Nominated for Master Instructor, 2014

Cardno ChemRisk

Senior Health Scientist

Heidi worked at Cardno ChemRisk as a Senior Health Scientist

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology

Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions

Nicotinic Receptors

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology

Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions

Nicotinic Receptors

Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation.

Am J Respir Crit Care Med

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology

Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions

Nicotinic Receptors

Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation.

Am J Respir Crit Care Med

Deletion of lynx1 reduces the function of α6* nicotinic receptors.

PLoS One. 2017 Dec 5;12(12):e0188715.

Cigarette smoke extract-induced suppression of caspase-3-like activity impairs human neutrophil phagocytosis.

Am J Physiol Lung Cell Mol Physiol

Varenicline blocks β2*-nAChR-mediated response and activates β4*-nAChR-mediated responses in mice in vivo.

Nicotine Tob Res

Mice expressing the ADNFLE valine 287 leucine mutation of the Β2 nicotinic acetylcholine receptor subunit display increased sensitivity to acute nicotine administration and altered presynaptic nicotinic receptor function.

Pharmacol Biochem Behav

Lithium alters measures of auditory gating in two strains of mice.

Biol Psychiatry

A novel genetic marker of decreased inflammation and improved survival after acute myocardial infarction.

Basic Res Cardiol. 2018 Aug 10;113(5):38. doi: 10.1007/s00395-018-0697-7.

Lipoic acid suppression of neutrophil respiratory burst: effect of NADPH.

Antioxid Redox Signa

Treatment with the catalytic metalloporphyrin AEOL 10150 reduces inflammation and oxidative stress due to inhalation of the sulfur mustard analog 2-chloroethyl ethyl sulfide.

Free Radic Biol Med

The 5-HT(1A) receptor active compounds (R)-8-OH-DPAT and (S)-UH-301 modulate auditory evoked EEG responses in rats.

Amino Acids

α6* nicotinic acetylcholine receptor expression and function in a visual salience circuit.

J Neuroscience

Habenular TCF7L2 links nicotine addiction to diabetes

Nature

Diabetes is far more prevalent in smokers than non-smokers, but the underlying mechanisms of vulnerability are unknown. Here we show that the diabetes-associated gene Tcf7l2 is densely expressed in the medial habenula (mHb) region of the rodent brain, where it regulates the function of nicotinic acetylcholine receptors. Inhibition of TCF7L2 signalling in the mHb increases nicotine intake in mice and rats. Nicotine increases levels of blood glucose by TCF7L2-dependent stimulation of the mHb. Virus-tracing experiments identify a polysynaptic connection from the mHb to the pancreas, and wild-type rats with a history of nicotine consumption show increased circulating levels of glucagon and insulin, and diabetes-like dysregulation of blood glucose homeostasis. By contrast, mutant Tcf7l2 rats are resistant to these actions of nicotine. Our findings suggest that TCF7L2 regulates the stimulatory actions of nicotine on a habenula–pancreas axis that links the addictive properties of nicotine to its diabetes-promoting actions.

Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.

Biochem Pharmacol.

Role of reactive oxygen and nitrogen species in olfactory epithelial injury by the sulfur mustard analogue 2-chloroethyl ethyl sulfide.

Am J Respir Cell Mol Biol

The interaction of the Chrna5 D398N variant with developmental nicotine exposure.

Genes Brain Behav. 2018 Sep;17(7):e12474.

Nicotine reverses hypofrontality in animal models of addiction and schizophrenia

Nature Medicine

Chronic treatment with varenicline changes expression of four nAChR binding sites in mice.

Neuropharmacology

Alpha-lipoic acid induces elevated S-adenosylhomocysteine and depletes S-adenosylmethionine.

Free Radic Biol Med

Developmental nicotine exposure precipitates multigenerational maternal transmission of nicotine preference and ADHD-like behavioral, rhythmometric, neuropharmacological, and epigenetic anomalies in adolescent mice.

Neuropharmacology

Presynaptic Nicotinic Acetylcholine Receptors: Subtypes and Functions

Nicotinic Receptors

Airway obstruction due to bronchial vascular injury after sulfur mustard analog inhalation.

Am J Respir Crit Care Med