Crystal Walline

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CrystalC. Walline

Crystal C. Walline

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Oct 23, 2019
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Textbook used: Yes
Would take again: No
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Professor Walline is unorganized but very lenient when it comes to grading. Be sure to pay attention to her power points when taking the tests. You will do a group presentation that will be graded as an exam grade.

5 Reviews Pending Approval

Biography

University of North Carolina Pembroke - Biology

Dedicated to student-focused, holistic mentoring and enhancing learning using evidence-based, inclusive teaching.
Higher Education
Crystal C.
Walline
Pembroke, North Carolina
In 2019 Professor Walline and 2 other UNCP faculty founded the Biomedical Laboratory at UNCP. This created a unique space dedicated to undergraduate-driven research focused on genetic, molecular biology, and immunology techniques. Previously, her postdoctoral research generated 15 peer-reviewed publications from 3 key projects which investigated: 1) The pathogenesis of Multiple Sclerosis using the MOG-EAE mouse model. 2) Cellular immunity and inflammation in mouse models of allergic lung disease and poxvirus respiratory infection. 3) Immune dysfunction in PBMN cells from chronic heavy drinkers (alcoholics). Currently, she is investigating biomarkers of inflammation in saliva and gingival crevicular fluid with future plans to expand this research to study autoimmune disorders, including Sjögren's Syndrome.

Professor Walline uses her interdisciplinary background to provide comprehensive and engaging teaching experiences to students studying biology or pursuing a health career. She currently teaches Anatomy & Physiology I and Immunology but has previously taught Intro Bio, Cell, Genetics, Research Methods and non-majors courses.

Passionate about holistic mentoring, Professor Walline provides an individualized approach to academic advising. Additionally, she serves on several advising committees and is co-chair for the University College Student Success Steering Committee advising group.

Experience

  • Purdue University

    Research/Teaching Assistant

    Research Assistant for Dr. Eric L. Barker in the Department of Medicinal Chemistry & Molecular Pharmacology (MCMP). Teaching assistant for the School of Pharmacy.


    The purpose of my research was to 1) use species-scanning mutagenesis to determine the role of TMH III in antagonist recognition and substrate translocation, and 2) to use a recently developed homology model and existing mutagenesis data to determine an antagonist binding site. Investigation focused on the recognition of antidepressants, cocaine analogs, and amphetamine analogs by SERT by utilizing Comparative Molecular Field Analysis (CoMFA) selectivity fields using data generated from heterologous expression systems expressing human SERT.

  • The University of North Carolina at Pembroke

    Assistant Professor

    Promote excellence in teaching and learning and prepare students for a lifetime of intellectual inquiry and community engagement.

    https://orcid.org/0000-0002-0116-7991
    https://www.researchgate.net/profile/Crystal_Walline
    Twitter: @ProfWalline

    UNC's Morehead Planetarium & Science Center IMPACTS Program Science Ambassador
    Co-chair of the University College Student Success Steering Committee – Advising Group
    Advising & Retention Council Member
    Advising Task Force Member
    EAB Student Success Collaborative Training Specialist
    Social Media Co-administrator for UNCP Department of Biology
    Certified in Accessibility & Inclusive Teaching.

    Courses taught:
    BIOL 2210: Human Anatomy & Physiology I
    BIOL 3810: Immunology

  • Indiana University School of Medicine

    Postdoctoral Fellow - Immunology

    Postdoctoral mentor: Janice Blum, PhD
    Collaborators: David Wilkes, MD; Randy Brutkiewicz, PhD; Mark Kaplan, MD
    Previously, I focused on studies to investigate the molecular mechanisms which contribute to pulmonary inflammation associated with asthma. A key goal is to understand the role of both innate and adaptive immunity on pulmonary allergic disease, and to use in vivo and in vitro analyses of immune cell function to determine the effects of subsequent virus infection in regulating inflammation. Studies suggest that pulmonary delivery of vaccinia virus leads to changes in the trafficking of specific dendritic cell and macrophage populations in the lung early after infection, and alterations in anti-viral antibodies and T cell effector cells late in infection. Our efforts to analyze phenotypic and functional changes in these innate and adaptive immune cells have suggested that virus-specific T effector cells are recruited, but fail to control lung inflammation and tissue injury. I am currently using in vitro approaches to determine how pro-allergic cytokines alter co-stimulatory molecule expression on macrophages, which may lead to functionally impaired T cells.

  • Monmouth College

    Visiting Assistant Professor

    Previously, I was a Visiting Assistant Professor of Biology at Monmouth College, a private, residential, liberal arts college in west-central Illinois. I taught majors-level biology to freshmen through seniors in the subjects of Anatomy & Physiology, Genetics, Cell Biology, Biological Research Methods and Ecology/Evolution. I also taught a junior-level general education thematic seminar on eastern philosophies and religions and a current topics seminar on health topics in Immunogy for the Honors Program.

    I developed research collaborations with faculty in the department of chemistry to determine novel uses for synthetically-derived anti-microbial peptides as well as mentored 9 senior research projects in biology, biopsychology and exercise science.

    Courses taught:
    Introduction to Ecology, Evolution and Diversity
    Research Methods
    Cell Biology
    Genetics
    Human Anatomy & Physiology
    Honors
    Reflections

  • Indiana University Health

    Postdoctoral Fellow - Immunology

    Multiple sclerosis is a disorder where immune cells attack the myelin sheath that protects the brain and spinal cord and allows electrical signals to be carried between cells. The disruption of these electrical signals leads to muscle weakness or spasms, motor incoordination, changes in sensation, and visual, speech and swallowing problems. Experimental allergic encephalomyelitis (EAE) is an animal model of MS that enables researchers to study the involvement of various cells, chemicals, and proteins in the development of MS. Interleukin 7 (IL-7) is a signaling cytokine that binds to the IL-7 cell surface receptor (IL-7R) and induces new activity in the cell to support the growth and expansion of immune cells. Previously, I tested the hypothesis that the activation of IL-7/IL-7R system is critical in the pathogenesis of central nervous system inflammation and demyelination in experimental allergic encephalomyelitis model of multiple sclerosis. Additionally, I investigated the role pro- and anti-inflammatory cytokines, memory T cells and regulatory T cells play in the onset, progression and relapse of EAE.

Education

  • Purdue University

    Ph.D.

    Neuropharmacology and Molecular Biology
    I completed the degree requirements for both the Department of Medicinal Chemistry & Molecular Pharmacology and the Interdisciplinary Program in Neuroscience.

  • Purdue University

    Research/Teaching Assistant


    Research Assistant for Dr. Eric L. Barker in the Department of Medicinal Chemistry & Molecular Pharmacology (MCMP). Teaching assistant for the School of Pharmacy. The purpose of my research was to 1) use species-scanning mutagenesis to determine the role of TMH III in antagonist recognition and substrate translocation, and 2) to use a recently developed homology model and existing mutagenesis data to determine an antagonist binding site. Investigation focused on the recognition of antidepressants, cocaine analogs, and amphetamine analogs by SERT by utilizing Comparative Molecular Field Analysis (CoMFA) selectivity fields using data generated from heterologous expression systems expressing human SERT.

  • Millikin University

    B.S.

    Experimental Psychology and Chemistry

Publications

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • A role for NADPH oxidase in antigen presentation.

    Frontiers in Immunology

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • A role for NADPH oxidase in antigen presentation.

    Frontiers in Immunology

  • The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

    Journal of Biological Chemistry

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • A role for NADPH oxidase in antigen presentation.

    Frontiers in Immunology

  • The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

    Journal of Biological Chemistry

  • Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production.

    Respiratory Research

  • Early activation of peripheral monocytes with hallmarks of M1 and M2 monocytic cells in excessive alcohol drinkers: a pilot study.

    Journal of Investigative Medicine

  • Virus-encoded ectopic CD74 enhances poxvirus vaccine efficacy.

    Immunology

  • Differential regulation of CD4(+) T helper cell responses by curcumin in experimental autoimmune encephalomyelitis.

    Journal of Nutritional Biochemistry

  • Allergic Airway Disease in Mice Alters T and B Cell Responses during an Acute Respiratory Poxvirus Infection

    PLOS ONE

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • Opposing roles of STAT4 and Dnmt3a in Th1 gene regulation.

    Journal of Immunology

  • A role for NADPH oxidase in antigen presentation.

    Frontiers in Immunology

  • The transcription factor Twist1 limits T helper 17 and T follicular helper cell development by repressing the gene encoding the interleukin-6 receptor α chain.

    Journal of Biological Chemistry

  • Donor lung derived myeloid and plasmacytoid dendritic cells differentially regulate T cell proliferation and cytokine production.

    Respiratory Research

  • Dynamic interplay of T helper cell subsets in experimental autoimmune encephalomyelitis.

    World Journal of Immunology

Positions

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

  • American Association of Immunologists

    Regular member

    urn:li:fs_position:(ACoAAAIhuTEBmslmBs6dEiViDH2KtsJ2mMdo-uY,843707444)

BIO 2110

3.5(4)

  • Level:
  • Credit hours: 0

BIO 3810

4(1)

  • Level:
  • Credit hours: 0

BIO 2100

3(1)

  • Level:
  • Credit hours: 0
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