Resume

• 2005

  Institut für Reine und Angewandte Chemie

  Texas A&M University

  Universität Oldenburg

  GE

  API-Mass Spectrometric Investigations on the Mechanism of Organocatalytic Reactions\n\nDuring my stay at the institute I introduced the use of extractive electrospray ionization EESI to the detection and identification of short-lived intermediates in catalyzed reactions. This novel technology offered the means to validate the catalytic cycle proposed for the organo-catalyzed aldol reaction

  recognized as a powerful tool for the construction of new carbon–carbon bonds.\n\nPresentation Award at the “Berichtskolloquium zum DFG Schwerpunktprogramm Organokatalyse”

  Max Planck Institut für Kohlenforschung

  Germany

  2006\nTitle: ESI-MS Study on the Aldol Reaction Catalyzed by L-Proline

  Post Doctoral Research Associate

  Institut für Reine und Angewandte Chemie

  Summary: Biotechnology contract research organization centered in the development of innovative bioanalytical and bioinformatics tools oriented to metabolomics. During this time

  I produced intellectual property currently being materialized in two patents

  one of them concerning the development of a new atmospheric pressure ionization source.\n\nResponsibilities: Head of scientific research operations and collaborations. Design and direction of research projects. Definition of timelines for working teams (5 direct reports)

  collaborators and CROs. Budget management. Staff hiring

  training and coordination. Reviewing of SOPs

  validation procedures and company reports. Representation of the company at international forums.\n\nAwarded Research Projects:\n2010-2012. MetaboSearch. Informatic tool for the automatic detection and identification of metabolites in biofluids\nTORRES QUEVEDO Project financed by the Spanish Ministry of Science and Innovation. 2010-2011. Urine-MS. Design and development of a kit for the experimental optimization of mass spectrometric analysis of urine samples\nGAITEK Project financed by the Basque Department of Technology and Innovation. 2009-2011. Metabol. Creation of a mass spectrometric platform for the identification and absolute quantification of metabolites in complex mixtures\nINNPACTO Project financed by the Spanish Ministry of Science and Innovation.\n2008-2013. TotalMatch. Design and development of a kit for the identification and absolute quantification of metabolites in complex mixtures\nNETS Project financed by the Basque Department of Technology and Innovation.

  Scientific Director

  Spain

  MD Renal

  Summary: Biotechnology contract research organization centered in the area of human health

  with pioneering UPLC-MS and UPLC-MSMS biomarker systems for the early diagnosis of liver disease. OWL incorporated MD Renal in 2011. Recently

  OWL initiated the validation of LiverTox

  a Biomarker System I designed. LiverTox’s patent is in the process of registration.\n\nResponsibilities: Direction of research projects and external collaborations with universities

  CRO and industry. Design new research projects in accordance with corporate

  customer and regulatory guidelines. Budget management. Supervision of departmental personnel (14 direct reports). Representation of the company in technical meetings with clients.\n\nAwarded Research Projects:\n2010-2013. Dendria. Innovative solutions to accelerate the identification and development of drugs in pathologies of the neural system\nCENIT Project financed by the Spanish Ministry of Science and Innovation.\n2010-2013. LiverBiomark. Development of biomarkers for determining the degree of hepatic fibrosis and patient prognosis of acute hepatic diseases using advanced metabolomics tools\nINNPACTO Project financed by the Spanish Ministry of Science and Innovation.\n2010-2012. LiverTox. Software development for the prediction and quantification of hepatotoxicity based on metabolomic profile analysis in serum\nBIZKAIBERRI DBF Project financed by the Vizcaya Office for Industrial Promotion.\n2010-2012. AntiLipid. Development of a prototype for the preservation

  extraction and diagnosis based on monoclonal antibodies against lipid markers of hepatic disorders\nETORGAI Project financed by the Basque Department of Technology and Innovation. 2010-2012. BioDetect. New detection techniques for biomarkers\nETORGAI Project financed by the Basque Department of Technology and Innovation.

  R&D Director

  Spain

  OWL Metabolomics

  Corpus Christi

  Texas Area

  Assistant Professor Of Chemistry

  Texas A&M University

  Summary: Contract research organization specialized in early phase clinical pharmacology

  biological characterization methods

  and scientific affairs services. The bioanalytical services provided by PRACS included the support of more than 5

  000 bioanalytical studies and the analysis of more than 600

  000 samples annually. PRACS Institute ceased the entirety of its North American operations abruptly on March 20

  2013.\n\nResponsibilities: Direction of all method development and validation activities at PRACS bioanalytical facilities in Toronto and Fargo

  in accordance with corporate

  customer and regulatory guidelines. Daily management of personnel and departmental activities. Providing scientific and technical guidance to internal teams and clients.\n\nSpecifics: 9+6 direct reports between principal investigators

  validation chemists and quality control specialists • API 4000 • QTRAP 4000 AB Sciex

  QTRAP 4500 AB Sciex • QTRAP 5500 AB Sciex

  • Quatro Altima Micromass Waters • Agilent 1200 HPLC Pumps with Column oven and Degassers

  • Agilent 1100 HPLC Pumps with Column oven and Degassers • CTC PAL Auto samplers

  Cohesive auto samplers

  waters auto samplers • Analyst 1.5.1 • Masslynx • Watson LIMS 7.4

  R&D Manager

  Toronto

  Canada Area

  PRACS Institute

• 2004

  Centre for Research in Mass Spectrometry

  MD Renal

  Corpus Christi

  Texas Area

  Summary. This academic position allows me to impart lectures and laboratory training in different fields of Chemistry and Life Sciences. I also help my students to prepare their transition from university to industry

  introducing them into SOP

  GLP

  GMP and other fundamental knowledge required in their future scientific endeavors. During this time at TAMU-CC I have scored an average of 4.65/5.00 in my Students Course Evaluations.\n\nServices\n2015-16. Member of the Center for Faculty Excellence (CFE) Committee 2014-16. Organic Chemistry Laboratories Coordinator at PENS\n2014. Chemistry Coordinator at The Corpus Christi Regional Science Olympiad\nCurriculum Development\n2015. Advanced Inorganic Chemistry. The lecture section of this course includes direct application in environmental sciences or biomedicine. Its laboratory section focuses on introducing students to applied research topics in Supramolecular Inorganic Chemistry.\n2016. Undergraduate Research in Organic Chemistry. The Organic Chemistry Laboratories Courses are invested in providing students with the research mannerisms required for future professional endeavors. Students participate in research lines focusing on biomimicks

  drug nanocarries

  and biosensors.\n2016. Molecular Modeling in Medicinal Chemistry. This course is currently in preparation. It intends to offer students inscribed in “Drugs

  Toxins and Natural Products” with dry laboratories oriented to achieve introductory knowledge in Computational Chemistry.

  Professor of Chemistry (Exchange Visitor)

  Texas A&M University

  York University

  CA

  Nucleation Kinetic Effect on Amyloid β Protein (βAP) aggregation.\n\nI initiated an investigation concerned with Alzheimer’s Disease. My research focused on the interaction of transition metal ions with Amyloid β-protein pre-aggregates. The project was an exploratory overview of the possibility of using MS as tool for the investigation of aggregation processes

  establishing a base for more detailed studies of the behaviour of these specific kinds of proteins.\n\nThe Centre’s commitment to the development of new MS technologies allowed for in-depth examination of the fundamentals of the technique. During my time at York University

  my knowledge of MS was enriched through contact with leading professionals in the field

  and I was fortunate to witness the design and preliminary studies for the construction of a custom-built ion mobility MS apparatus.

  Post Doctoral Research Associate

  Centre for Research in Mass Spectrometry

• 2000

  Doctor of Philosophy (Ph.D.)

  My dissertation addressed the complexation mechanisms of molecular containers with small guests

  their photophysical properties

  and the potential use of such systems. These studies produced noteworthy results

  including the largest fluorescence lifetime described for an organic compound – above one microsecond – with clear applications such as a signaling nano-device.

  Physical Organic Chemistry

  Swiss National Science Foundation within the Research Program “Supramolecular Functional Materials”\nProject: Cucurbiturils as Molecular Containers: The Mechanism of Complexation of Small Guests

  the Effects of the Inclusion on their Photophysical Properties

  and Potential Applications

  Basel University

  CH / Jacobs University Bremen

  DE

• 1985

  English

  Spanish

  Chemistry

  Photochemical Reactions

  Universidad de Alcalá

• Bioanalysis

  Photochemistry

  GMP

  Fluorescence

  GLP

  Lifesciences

  Metabolomics

  Physical Organic Chemistry

  Chemistry

  Organic Chemistry

  Supramolecular Chemistry

  CRO

  Validation

  R&D

  Mass Spectrometry

  Sop

  FDA

  Protein Chemistry

  Analytical Chemistry

  BioAnalytical Chemistry

  Urine-MS. Design and development of a kit for the experimental optimization of mass spectrometric analysis of urine samples

  Urine-MS. Design and development of a kit for the experimental optimization of mass spectrometric analysis of urine samples

  LiverBiomark. Development of biomarkers for determining the degree of hepatic fibrosis and patient prognosis of acute hepatic diseases using advanced metabolomics tools

  BioDetect. New detection techniques for biomarkers

  TotalMatch. Design and development of a kit for the identification and absolute quantification of metabolites in complex mixtures

  Electrospray Ionization Mass Spectrometric Study on the Direct Organocatalytic α-Halogenation of Aldehydes

  Two Mechanism of Slow Host-Guest Complexation between Cucurbit[6]uril and Cyclohexyl methylamine: pH- Responsive Supramolecular Kinetics

  Transition-Metal-Promoted Chemoselective Photoreactions at the Cucurbituril Rim

  Mechanism of Host-Guest Complexation by Cucurbituril

  Exploiting Long-Lived Molecular Fluorescence

  AntiLipid. Development of a prototype for the preservation

  extraction and diagnosis based on monoclonal antibodies against lipid markers of hepatic disorders

  Metabol. Creation of a mass spectrometric platform for the identification and absolute quantification of metabolites in complex mixtures

  Selective Fluorescence Quenching of 2

  3-Diazabicyclo[2.2.2]oct-2-ene by Nucleotides

  MetaboSearch. Software development for the automatic detection and identification of metabolites in biofluids

  ESI-MS Study on the Aldol Reaction Catalyzed by L-proline

  Polarizabilities Inside Molecular Containers

  LiverTox. Software development for the prediction and quantification of hepatotoxicity based on metabolomic profile analysis in serum

  Cucurbiturils: Molecular Nanocapsules for Time-Resolved Fluorescence-based Assays

  Dendria. Innovative solutions to accelerate the identification and development of drugs in pathologies of the neural system

  Serum UPLC-MS/MS Metabolic Profiling in an Experimental Model for Acute-Liver Injury Reveals Potential Biomarkers for Hepatotoxicity

  Electron-Transfer-Catalyzed Dimerization of trans-Anethole: Detection of the Distonic Tetramethylene Radical Cation Intermediate by Extractive Electrospray Ionization Mass Spectrometry

  Cesar A.

  PRACS Institute

  OWL Metabolomics