Berj Bardakjian
- Courses4
- Reviews24
- School: University of Toronto
- Campus: St. George Campus
- Department: Electrical Engineering
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Location:
Toronto, ON - Dates at University of Toronto: April 2009 - May 2019
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Biography
University of Toronto St. George Campus - Electrical Engineering
Experience
University of Toronto
Professor
Berj worked at University of Toronto as a Professor
Education
McMaster University
Doctor of Philosophy (Ph.D.)
Electrical and Biomedical Engineering
McMaster University
Doctor of Philosophy (Ph.D.)
Electrical/Biomedical Engineering
Publications
Stochastic amplification of calcium-activated potassium currents in Ca2+ microdomains
Journal of Computational Neuroscience
We demonstrated a novel mechanism by which the presence of noise amplifies the activity of neuronal calcium-sensitive potassium channels.
Stochastic amplification of calcium-activated potassium currents in Ca2+ microdomains
Journal of Computational Neuroscience
We demonstrated a novel mechanism by which the presence of noise amplifies the activity of neuronal calcium-sensitive potassium channels.
The origin of segmentation motor activity in the intestine
Nature Communications
The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by interstitial cells of Cajal associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase-amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in the networks of ICC.
The origin of segmentation motor activity in the intestine
Nature Communications
The segmentation motor activity of the gut that facilitates absorption of nutrients was first described in the late 19th century, but the fundamental mechanisms underlying it remain poorly understood. The dominant theory suggests alternate excitation and inhibition from the enteric nervous system. Here we demonstrate that typical segmentation can occur after total nerve blockade. The segmentation motor pattern emerges when the amplitude of the dominant pacemaker, the slow wave generated by interstitial cells of Cajal associated with the myenteric plexus (ICC-MP), is modulated by the phase of induced lower frequency rhythmic transient depolarizations, generated by ICC associated with the deep muscular plexus (ICC-DMP), resulting in a waxing and waning of the amplitude of the slow wave and a rhythmic checkered pattern of segmentation motor activity. Phase-amplitude modulation of the slow waves points to an underlying system of coupled nonlinear oscillators originating in the networks of ICC.
