Biography
University of North Carolina Chapel Hill - Biomedical Engineering
Chief Scientist Officer & Co-Founder of Xona Microfluidics, LLC
Research
Anne
Taylor
Durham, North Carolina
Dr. Anne Marion Taylor, Ph.D., is the Chief Scientist Officer & a co-founder of Xona Microfluidics, LLC. She was faculty at UNC-Chapel Hill for 9 years before moving her lab to Xona. At Xona, her lab continues to conduct NIH-funded research.
Xona provides to the neuroscience research community unique, disposable platforms for cellular organization and to sustain viability in vitro. Our neuron devices and chips provide compartmentalization, fluidic isolation and improved cellular organization over traditionally chaotic neuronal cell cultures.
Xona Microfluidics offers a wide selection of devices for neuron cell culture. Our new XonaChips™ are pre-assembled and easy to use. They are especially useful for culturing human stem cell-derived neurons. The XonaChip™ offers the researcher a novel method to isolate and grow axons, ultimately delivering the ability to study neuronal response to axonal damage due to disease or injury in an isolated fluidic environment.
Xona Microfluidics distributes and supports its products directly, as well as through qualified distributors, to hundreds of research organizations in over 20 countries.
Specialties: microfluidics, micro-devices for cell-based application, neurobiology, axonal protein-synthesis, synapse development, synaptic plasticity.
Experience
UNC Neuroscience Center
Primary Faculty
www.med.unc.edu/neuroscience
University of North Carolina at Chapel Hill
Faculty
Anne worked at University of North Carolina at Chapel Hill as a Faculty
Caltech
Postdoctoral Scholar
My research involves developing and using microfluidic devices to study cellular mechanisms of synaptic plasticity. Lab of Erin Schuman.
UC Irvine
Postdoctoral Scholar
My work involved using the microfluidic platform I developed as a graduate student to isolate and characterize the mRNA population in cortical axons. Lab of Carl Cotman.
Xona Microfluidics, LLC
Chief Scientist & Co-founder
Xona provides innovative technology for experimental neuroscience.
Education
Washington University in St. Louis
BS
Engineering
University of California, Irvine
Doctor of Philosophy (PhD)
Bioengineering and Biomedical Engineering
UC Irvine
Postdoctoral Scholar
My work involved using the microfluidic platform I developed as a graduate student to isolate and characterize the mRNA population in cortical axons. Lab of Carl Cotman.
Publications
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Lab-on-a-Chip
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Lab-on-a-Chip
Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
Journal of Visualized Experiments
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Lab-on-a-Chip
Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
Journal of Visualized Experiments
Cloning SU8 silicon masters using epoxy resins to increase feature replicability and production for cell culture devices
Biomicrofluidics
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Lab-on-a-Chip
Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
Journal of Visualized Experiments
Cloning SU8 silicon masters using epoxy resins to increase feature replicability and production for cell culture devices
Biomicrofluidics
Magnetic alignment of microelements containing cultured neuronal networks for high-throughput screening
Journal of Biomolecular Screening
Distal axotomy enhances retrograde presynaptic excitability onto injured pyramidal neurons via trans-synaptic signaling.
Nature Communications
Messenger RNAs localized to distal projections of human stem cell derived neurons
Scientific Reports
Multi-compartment microfluidic device geometry and covalently bound poly-D-lysine influence neuronal maturation
Frontiers in Bioengineering and Biotechnology
Unique axon-to-soma signaling pathways mediate dendritic spine loss and hyper-excitability post-axotomy
BioRxiv 642207
The proteasome controls presynaptic differentiation through modulation of an on-site pool of polyubiquitinated conjugates
Journal of Cell Biology
Passive microfluidic chamber for long-term imaging of axon guidance in response to soluble gradients
Lab-on-a-Chip
Compartmentalization of Human Stem Cell-Derived Neurons within Pre-Assembled Plastic Microfluidic Chips
Journal of Visualized Experiments
Cloning SU8 silicon masters using epoxy resins to increase feature replicability and production for cell culture devices
Biomicrofluidics
Magnetic alignment of microelements containing cultured neuronal networks for high-throughput screening
Journal of Biomolecular Screening
Use of pre-assembled plastic microfluidic chips for compartmentalizing primary murine neurons
Journal of Visual Experimentation
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